Neuronal tracing with DiI: decalcification, cryosectioning, and photoconversion for light and electron microscopic analysis.

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Neuronal tracing with DiI: decalcification, cryosectioning, and photoconversion for light and electron microscopic analysis.

The molecule 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (DiI) is a fluorescent dye which diffuses within cell membranes. The properties of DiI diffusion and fluorescence are maintained in aldehyde-fixed tissue, thereby allowing selective neuronal tracing post mortem. We describe three modifications of this tracing method. First, while DiL diffuses along neuronal membrane...

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Bone decalcification is a time-consuming process. It takes weeks and preservation of the tissue structure depends on the quality and velocity of the demineralization process. In the present study, a decalcification methodology was adapted using microwaving to accelerate the decalcification of rat bone for electron microscopic analysis. The ultrastructure of the bone decalcified by microwave ene...

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ژورنال

عنوان ژورنال: Journal of Histochemistry & Cytochemistry

سال: 1990

ISSN: 0022-1554,1551-5044

DOI: 10.1177/38.5.2185313